Actor Dwayne Johnson (also known as ‘The Rock’) has been taking Prozac (fluoxetine), a selective serotonin reuptake inhibitor, for his depression for some time now. However, he has found that the drug has become less effective over time. This effect may be due to serotonin receptor_____________ produced by the drug.

A 35-year-old woman underwent multiple surgeries after a car accident. Her surgeon prescribed 10 mg of Vicodin (acetaminophen+ hydrocodone) taken daily for her postoperative pain. The treatment provided adequate analgesia (pain relief). The accident led to a recurrence of her major depressive disorder, for which she renewed her use of anti-depressant fluoxetine (Prozac) at 20 mg/day. She was unaware that hydrocodone is an inactive prodrug and the substrate for CYP450-2D6 enzyme that transforms it to hydromorphone – an active form of this drug and the actual analgesic. She was also unaware that Fluoxetine is a strong CYP450-2D6 inhibitor. As result of this drug interaction she experienced:

Prolonged administration of a drug often requires to increase its dose to obtain the same effect. This is due to a well-known phenomenon called:

In the dose–response curve, a decrease in potency is indicated by a shift

During the process of behavioral drug tolerance, after repeated, frequent use of a drug in the same environment:

The nurse clarifies that the immune system failure theory states that:

The older adult has a better chance of adjusting to continued aging in positive ways if he or she:

What is a great way to keep the older adult involved in the community?

In chapter 10 of your text is the photo of a rose.  What fragrant compound is mentioned in its caption?

When providing teaching to the older adult, it is important for the nurse to: