You are a researcher in an exercise physiology lab. At rest,…

You are a researcher in an exercise physiology lab. At rest, you took a blood sample from one of your participants and found an increased level of a krebs/TCA/citric acid cycle enzyme (citrate synthase) compared to their baseline 6 months ago. Which assumption would be reasonable?

Nguyen – Autoimmunity My exam tips:  A brief answer is two…

Nguyen – Autoimmunity My exam tips:  A brief answer is two to three sentences in your answer. There may be more than one correct answer to my question. I am looking for how you best articulate your reasoning to support the answer.  (A)  Pick ONE of your favorite T cell types. Briefly describe how self-tolerance breakdown in central and peripheral tolerance can lead to autoimmunity (5 points).  (B)  Briefly describe the similarities and differences between molecular mimicry and bystander activation. (5 points)

Duarte – Transplantation Immunology In kidney transplantatio…

Duarte – Transplantation Immunology In kidney transplantation, a significant effort is put into reducing organ ischemia times and matching between donors and recipients, prior to transplantation. (A)  Briefly define the three key stages involved in the matching process when identifying a suitable donor kidney for a transplant recipient, and what specific immune responses or incompatibilities the transplant team aims to avoid with each stage. (6 points) (B)  Briefly define one main aspect of how ischemia-reperfusion injury activates the innate immune response and how it contributes to the activation of the recipient’s adaptive immune response and the development of graft rejection. (2 points)