Drug A, a calcium channel blocker, is 97% plasma protein bou…

Drug A, a calcium channel blocker, is 97% plasma protein bound (fup = 0.03); its hepatic plasma clearance is 475 mL/min. Predict the clearance (ml/min) in a patient with hypoalbumenia such that their fup is 0.055. (Use the full equations and do not simplify based on “E” status (i.e low, intermediate or high E).

The clearance of ibuprofen is 4 L/hr and its apparent volume…

The clearance of ibuprofen is 4 L/hr and its apparent volume of distribution (V) is 12 liters.  If 800 mg of ibuprofen were administered every 12 hours, what would be the steady-state trough plasma concentration (mg/L)?  Assume rapid and complete absorption that approximates i.v. bolus administration.