This acute leukemia contains primarily abnormal promyelocytes with heavy granulation, and the presence of Auer rods is abundant. The cells react near 100% with Sudan black and peroxidase; however, the reaction is negative for non-specific esterase. Disseminating intravascular coagulation (DIC) is frequently associated with this disorder. What is the FAB classification?

A 49-year-old woman was admitted to the hospital for easy bruising and menorrhagia. She had evidence of disseminated intravascular coagulation. Her white blood cell count is 3 x 10^9/L with 95% large, atypical mononuclear cells and some atypical bilobed cells. Many of these cells are packed with larger, purple-staining granules; some have multiple Auer rods; and all are strongly peroxidase-positive. What is the diagnosis?

What is the chromosomal abnormality in CML?

Relative erythrocytosis can be differentiated from secondary erythrocytosis and polycythemia vera by what clinical feature(s)?

TdT terminal deoxynucleotidyl transferase is found in 90% of acute __________ leukemia.

Bone marrow aspiration in myelofibrosis frequently results in a __________.

The lymphoblasts found in cases of B-cell acute lymphoblastic leukemia are indistinguishable by cytologic, cytochemical, and immunologic criteria from tumor cells found in __________.

What is the M/E ratio in patients with CML?

Which X-linked recessive disease is characterized by a granuloma formation as a result of the inability of neutrophils, monocytes, and eosinophils to kill microorganisms after normal engulfment?

“Pre-leukemia” myelodysplastic features in acute myeloid leukemia may include: