13. The following is the mechanism of resistance to amphote…
13. The following is the mechanism of resistance to amphotericin B: 1. As mutations in the gene encoding α- sterol demethylase enzyme 2. It occurs if ergosterol binding is impaired. 3. It occurs as accumulation of stepwise mutations of the protease gene 4. It occurs due to altered fungal DNA polymerase. 5. It occurs due to a multiple-layered thick cell wall, which may limit drug entry