Atopic dermatitis is a multifactorial, chronic relapsing, in…
Atopic dermatitis is a multifactorial, chronic relapsing, inflammatory disease characterized by xerosis, eczematous lesions, and pruritus. The latter usually leads to an “itch–scratch” cycle that may compromise the epidermal barrier. Skin barrier abnormalities in atopic dermatitis may result from mutations in the gene encoding for the protein filaggrin, which plays an important role in the formation of cornified cytosol. Barrier abnormalities render the skin more permeable to irritants, allergens, and microorganisms. Treatment of atopic dermatitis must be directed to: Select all that apply