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1.Where dоes the extrаvаsculаr destructiоn оf blood take place?2.List out the matrix composition used in Gel Method and mention the concentration of Rbc cell suspension used in the Gel Method?3.Notate the 2 major antigens in the Duffy system and mention the effect of proteolytic enzymes on these Rbc antigens?4.List out 2 characteristics of Donath Landsteiner antibody.5.Name the blood group system that may show a cell typing change during pregnancy? Are the antibodies produced against these Blood group system (RBC antigens) considered clinically significant? What class are they?