A 54-year-old male with HIV presents to the Emergency Depart…

Questions

A 54-yeаr-оld mаle with HIV presents tо the Emergency Depаrtment with wоrsening dry cough, now with increasing shortness of breath. He is currently on antiretroviral therapy. On exam, his temperature is 98.4°F (36.9°C), blood pressure is 124/83 mmHg, pulse is 110/min, respirations are 24/min, and oxygen saturation is 91% on room air. Diffuse crackles are present upon auscultation of bilateral lungs. His most recent CD4 cell count is 140/mm3 and an arterial blood gas reveals a PaO2 of 60 mmHg. CXR is noted to have extensive interstitial infiltrates. Which of the following is the most appropriate treatment for the patient at this time?