BCH4024 OC SP25 E3 Q1: Dr. Otto Warburg proposed that cancer…
BCH4024 OC SP25 E3 Q1: Dr. Otto Warburg proposed that cancer cells have an altered metabolism, one that is much more reliant on glycolysis for ATP production, which explains their ability to grow and metastasize. In the 80 years since the “Warburg Hypothesis” was presented, we have learned a lot about the biochemistry of cancer. The following 6 questions are focused on these findings. Cancer cells have a higher rate of glycolysis than their neighboring normal cells. One reason for this increased rate is the over-expression of hexokinase (HK). Given that most tumors have a limited supply of glucose, which statement below correctly describes a characteristic of hexokinase that would explain why this increased HK concentration would be an advantage to the cancer?