BCH4024 OC SP25 E3 Q3: Dr. Otto Warburg proposed that cancer…
BCH4024 OC SP25 E3 Q3: Dr. Otto Warburg proposed that cancer cells have an altered metabolism, one that is much more reliant on glycolysis for ATP production, which explains their ability to grow and metastasize. In the 80 years since the “Warburg Hypothesis” was presented, we have learned a lot about the biochemistry of cancer. The following 6 questions are focused on these findings. Another phenotype of many cancer cells is the overexpression of pyruvate dehydrogenase kinase 1(PDK1), the enzyme responsible for phosphorylating the pyruvate dehydrogenase complex. This increase in PDK1 activity would result in which of the following?