PJ is a 53-year-old male (92 kg, BMI 32) with a history of D…
PJ is a 53-year-old male (92 kg, BMI 32) with a history of Duchenne muscular dystrophy, diabetes mellitus, and hypertension who resides in a skilled nursing facility. He is brought to the hospital with confusion, shortness of breath, cough, and increased sputum production consistent with pneumonia. One month prior to presentation he received a 10 day course of ciprofloxacin for a suspected urinary tract infection. Vitals/labs on arrival include BP 71/48 (MAP 58), HR 127 beats/min, SCr 4.9 (baseline ~0.6), estimated CrCl = 21 ml/min, urine output 78 ml in last 4 hours, K = 5 (normal range = 3.5-5.1), RR 32 breaths/min, PaO2 = 54 on Room Air (PaO2/FiO2 ratio = 257), Glasgow Coma Scale (GCS) = 9, T 39.0 C, WBC 13.8 (normal range = 3.8-10.5), plt 350 (normal range = 160-370), ALT = 182 (normal range = 13-59), AST = 121 (normal range = 0-40), bilirubin = 1.4 (normal range = 0-1.4). Use Case 1 for questions 1-36