Peptide toxins in the venoms of fish-hunting cone snails (ge…
Peptide toxins in the venoms of fish-hunting cone snails (genus Conus) block synaptic transmission by inhibition of the nicotinic acetylcholine receptor (α-conotoxins), presynaptic voltage-sensitive calcium channels (ω-conotoxins), and muscle sodium channel potentials (μ-conotoxins). The sequence of α-conotoxin SI is ECCNPACGRHYSC with an amidated C-terminal. Researchers were able to use 2+, a complex of platinum with ethylenodiamine (en), to generate three regioisomers (isomers that differ in the intramolecular disulfide bond location). The isomers are: ECCNPACGRHYSC-NH2 ECCNPACGRHYSC-NH2 ECCNPACGRHYSC-NH2 ECCNPACGRHYSC-NH2 ECCNPACGRHYSC-NH2 Which of the regioisomers are going to produce two peptides following treatment with chymotrypsin?