A 12-year-old boy is brought to the clinic with polyuria, po…
A 12-year-old boy is brought to the clinic with polyuria, polydipsia, and unintentional weight loss over the past 2 weeks. He recently had a viral upper respiratory infection. Laboratory testing reveals hyperglycemia, ketonemia, and metabolic acidosis. Which of the following statements best describes the pathophysiology and typical onset of type 1 diabetes mellitus (T1DM)?