The next 2 questions are based on the following case: A chil…
The next 2 questions are based on the following case: A child presents with severe neurological defects. Blood tests indicate elevated serum levels of lactate, pyruvate and alanine. Cultures of skin fibroblasts showed deficient activity of the pyruvate dehydrogenase (PDH) complex. BCH4024 F25 E2 Q23: Both pyruvate and α-ketoglutarate are α-keto acids that undergo oxidative decarboxylation. What coenzyme is required for the decarboxylation step of these two α-keto acids?