A 24-year-old woman with a family history of autoimmune dise…
A 24-year-old woman with a family history of autoimmune disease has recurrent viral infections. Lab testing shows many self-reactive T cells in her periphery and unusually low numbers of regulatory T cells (Tregs). Based on what you learned about tolerance, explain why she is at high risk for autoimmunity. Your response should include negative selection, positive selection, central tolerance, and peripheral tolerance.