Question 1: Mechanotransduction and the Tumor Microenvironme…
Question 1: Mechanotransduction and the Tumor Microenvironment Part A: Define “cellular mechanotransduction” and list three distinct examples of physical forces or mechanical signals that cancer cells may encounter in the physiological environment. Part B: In the context of the “Physical World” interacting with cell biology, explain how the extracellular matrix (ECM) changes during tumorigenesis compared to normal tissue. Part C: Describe the “feed-forward” loop described in the lecture regarding ECM stiffening. How does increased tissue tension affect cancer cell phenotype?