A 45-year-old man presents to the clinic with a 5-day histor…
A 45-year-old man presents to the clinic with a 5-day history of fever (temperature 38.9°C/102°F), diffuse pruritic rash, and facial edema. He started taking carbamazepine 4 weeks ago for newly diagnosed trigeminal neuralgia. He reports that the rash initially began on his trunk and has progressively spread to his extremities. On examination, he has a generalized morbilliform eruption with areas of confluence on the trunk, along with periorbital edema and bilateral cervical lymphadenopathy. Laboratory studies show: WBC: 13,500/μL with 18% eosinophils Atypical lymphocytes: 12% Hemoglobin: 14.2 g/dL Platelets: 140,000/μL AST: 285 U/L (normal: 10-40) ALT: 320 U/L (normal: 10-40) Alkaline phosphatase: 95 U/L (normal: 30-120) Total bilirubin: 1.8 mg/dL (normal: 0.1-1.2) Creatinine: 1.8 mg/dL (baseline: 0.9 mg/dL) Sodium: 138 mEq/L Potassium: 4.2 mEq/L Which of the following features are characteristic of DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) syndrome? Select all that apply.