A 50-year-old woman presents with joint pain, swelling, and…
A 50-year-old woman presents with joint pain, swelling, and morning stiffness lasting more than an hour. She has tenderness and synovitis in multiple joints, including the wrists and small joints of the hands. Laboratory tests reveal positive rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies. Her erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are elevated. Radiographs show early erosive changes in the metacarpophalangeal joints. Which of the following is the most appropriate initial pharmacological treatment for this patient?