A 62-year-old female arrives at the hospital for cardiac sur…
A 62-year-old female arrives at the hospital for cardiac surgery. Pre-surgical laboratory testing is performed upon arrival. The results are as follows: Hemoglobin/Hematocrit: 10.5g/dL/ 32% Platelet count: 45,000/uL Type & Screen: B D-Positive with Negative antibody screen Crossmatch (XM): 2 out of 2 units of RBCs compatible Priot to surgery, a platelet transfusion is ordered. One B D-positive apheresis platelets (SDP) was issued and transfusion was begun after appropriate checks were completed. Twenty minutes later, the pre-operative clinic calls the blood bank to report that the patient was experiencing the following symptoms after receiving just 20mL of the platelets: urticaria, pruritis, dyspnea, hypotension, and angioedema of the tongue, throat, and eyes. The patient required immediate intubation to maintain her airway. Which of the following is the most likely type of transfusion reaction this patient was experiencing?