A 76-year-old female present for evaluation of excessive fat…
A 76-year-old female present for evaluation of excessive fatigue during the day, and the need for frequent afternoon naps. She has a long history of insomnia symptoms and admits to taking “sleeping medicine” for fifty years. Her daytime fatigue is a new symptom. An age-related increase in which of the following parameters may account for a prolongation in the metabolism of the sleep medication prescribed for this patient?