A colleague approaches you, their neighborhood structural bi…
A colleague approaches you, their neighborhood structural biologist, stating that they discovered a receptor-ligand pair that is essential for alligator reproduction. They used Alphfold to generate a 3D model of the receptor alone, ligand alone, and receptor-ligand complex, but they don’t know how to interpret the data. What scoring metrics would you consult to determine whether the structural models are reliable? Are these metrics different for the receptor alone versus the receptor-ligand complex?