Although autoimmune diseases exhibit diversity in the affect…
Although autoimmune diseases exhibit diversity in the affected tissues and severity of symptoms, a breach of T cell tolerance appears to be an important driver of autoimmunity in general. (a) How could a breach of T cell tolerance occur? (b) Describe the evidence that suggests a key role for T cells in mediating autoimmune disease. Your answer should include one or two specific pieces of evidence and an explanation for why the evidence points to the involvement of T cells.