An adult patient with schizophrenia is admitted to the inten…
An adult patient with schizophrenia is admitted to the intensive care unit after experiencing the first seizure of their lifetime. The patient was recently admitted to a nursing home after spending over 20 years in a state mental hospital. After consultation with the neurology and psychiatry services, the treating physician is concerned the patient’s seizure was due to a supratherapeutic level of clozapine (Clozaril). Which of the following changes would most likely account for the seizure?