Answer the following questions about the Makela and Mikkola…
Answer the following questions about the Makela and Mikkola paper entitled “Mesenchyme governs hair follicle induction”. Summarize which tissues were manipulated in the study, and which combinations led to hair follicle formation. The authors concluded that Wnt signaling and BMP inhibition are not sufficient to induce precocious (ie, early) hair follicle formation. Suggest an experiment that would identify the hair follicle initiating cue that originates in the mesenchyme.