BCH 4024 OC 3426 SP26 E2 Q17: A newly discovered four‑pass m…
BCH 4024 OC 3426 SP26 E2 Q17: A newly discovered four‑pass membrane protein shows one 22‑residue hydrophobic segment near residue 40 and three similar hydrophobic segments later in the sequence. Lys/Arg clusters are enriched on the loop/intervening sequence between helix 2 and helix 3. Given these observations, which overall orientation is most consistent with membrane topology rules?