An immunoglobulin (Ig) gene rearrangement can be identified in all of the following acute lymphoblastic leukemias except:

A phenotype workup is performed on a patient suspected to have ALL. The results indicate that one population of leukemic cells express myeloid markers, whereas others express T-cell markers. What is the most likely reason for this occurrence?

A 45-year-old female was evaluated by her physician because she had unexplained bruising on her upper torso. Patient history was unremarkable. Physical examination revealed a palpable liver and spleen.  CBCo   WBC count: 72  × 109/Lo   Hb: 8.7 g/dL o   Hct: 25% o   Normal indices o   PLT count: 55 × 109/L Differential: 40% blasts, 30% promyelocytes, 10% myelocytes, 4% metamyelocytes, 5% bands, 11% segemented neutrophils  Cytogenetics have been ordered – what abnormality is likely to be detected?   

The M:E ratio of a patient with AML typically displays:

Which of the following patient populations is most commonly afflicted with ALL?

Which markers are useful in immunophenotyping for leukemia/lymphoma of T cell-lineage?

A 7-year-old child is diagnosed with B-cell Acute Lymphoblastic Leukemia (B-ALL). Cytogenetic analysis reveals the presence of hyperdiploidy. Which of the following best describes the significance of these findings?

What is the cornerstone of treatment for Acute Promyelocytic Leukemia (APL)?

An adult patient presents with 44% blasts. The blasts are monomorphic, with abundant basophilic cytoplasm. The majority of blasts show prominent vacuolization (shown below). Cytogenetics shows translocation of the MYC gene (8q24) to the IgH chain locus . What is the diagnosis?

Match the following mechanisms of action with the appropriate medications.