A 44-year-old woman presents with facial edema, new-onset hypertension, and cola-colored urine that began one week after recovering from streptococcal pharyngitis. Urinalysis demonstrates 3+ protein, dysmorphic red blood cells, and RBC casts. Serum creatinine is elevated. Which diagnosis is most likely?

A 45-year-old woman has obesity and recently started semaglutide for weight management. Which finding indicates successful early treatment?

A 69-year-old man with hypertension and stable coronary artery disease is newly diagnosed with primary hypothyroidism. His calculated full replacement dose is approximately 120 mcg/day. Which initial levothyroxine prescription is most appropriate?

A 64-year-old woman presents after an inversion ankle injury. She has tenderness over the posterior edge of the lateral malleolus and is unable to bear weight for four steps.According to the Ottawa Ankle Rules, what is the next step?

A 76-year-old man with long-standing benign prostatic hyperplasia reports constant dribbling of urine, a weak urinary stream, hesitancy, and the sensation that his bladder never completely empties. He denies urgency or dysuria. Post-void residual volume is 425 mL. Which type of urinary incontinence is most likely?

A patient has persistent right upper quadrant pain despite a normal abdominal ultrasound. Clinical suspicion for acute cholecystitis remains high. Which diagnostic study is indicated next?

A 72-year-old man presents to your primary care office with low back pain that began yesterday after lifting a heavy flowerpot. He describes localized lumbar pain that is worse with movement and improves with rest. He denies fever, chills, weight loss, history of malignancy, intravenous drug use, bowel or bladder dysfunction, saddle anesthesia, or lower extremity weakness. On examination, there is tenderness over the lumbar paraspinal muscles. Straight leg raise testing is negative bilaterally, lower extremity strength is 5/5, sensation is intact, and deep tendon reflexes are normal. Which of the following is the most appropriate initial management?

A 40-year-old woman is newly diagnosed with hyperthyroidism. During the visit she asks whether her eye irritation and “bulging eyes” are related to her thyroid condition. Which diagnosis best explains these findings?

A 56-year-old man presents with a 3-day history of fatigue, decreased urine output, and dark-colored urine. He denies dysuria, urinary frequency, urgency, or flank pain. Two weeks ago, he completed treatment for streptococcal pharyngitis. His blood pressure is 168/94 mmHg, and physical examination demonstrates bilateral lower extremity edema. Laboratory studies reveal: Urine dipstick: 3+ blood, 2+ protein, negative nitrites, negative leukocyte esterase Urine microscopy: Dysmorphic RBCs, numerous RBC casts, no bacteria Urine culture: No growth after 48 hours Serum creatinine: 2.6 mg/dL (baseline 0.9 mg/dL) eGFR: 29 mL/min/1.73 m² UACR: 620 mg/g Based on these findings, what is the most appropriate next step?

Deterrence seeks to: