A 63-year-old male with chronic GERD has been taking omepraz…

A 63-year-old male with chronic GERD has been taking omeprazole daily for 3 years. He presents with fatigue and numbness in his feet. Laboratory results reveal macrocytic anemia and low serum vitamin B12 levels. Which of the following best explains the mechanism underlying this adverse effect?  

A 62-year-old postmenopausal woman presents for evaluation o…

A 62-year-old postmenopausal woman presents for evaluation of osteoporosis. She has no history of fractures but reports a family history of hip fractures in her mother. Her dual-energy X-ray absorptiometry (DEXA) scan shows a T-score of -2.6 at the lumbar spine. She has no significant renal or liver disease. Laboratory tests, including calcium, vitamin D, and renal function, are within normal limits. Which of the following is the most appropriate initial treatment for this patient?