Melatonin is compared to placebo for sleep in a single-group…

Melatonin is compared to placebo for sleep in a single-group randomized cross-over study (n=328). Participants are randomized to receive melatonin or placebo for 3 months and then take the other agent for 3 months following a 1-week washout period. Which of the following tests would be most appropriate to determine if this is a statistically significant difference in mean sleep latency (i.e., mean minutes to fall asleep)?

A non-inferiority study compared risankizumab (intervention)…

A non-inferiority study compared risankizumab (intervention) to secukinumab (standard of care) for at least 90% improvement in plaque psoriasis symptoms. An NI margin of 12% was used. Risankizumab was found to achieve a 90% symptom improvement in 73.8% of patients and in secukinumab 65.6% of patients.  95%CI 0.8 to 38.8%). Which of the following is the best interpretation of these results. Compared to secukinumab: