The physiologically based model of disposition is more complex than the one or two compartment models.

Biotransformation has the ability to produce a metabolite that is more toxic than the parent compound.

Toxicants bound to plasma proteins are more prone to cross cell membranes because they are more likely to be recognized by the cell.

Mercury bioaccumulates in the food chain.

Which of the following is NOT a specific aspect of disposition that is of primary importance?

Heavy metals typically reside in bone for decades.

The persistence of DDT in the body is related to its lipophilic nature.

Which exposure pathway has the fastest uptake in the human body?

A fish is exposed to a water environment that has concentration of 100ug/L of toxicant A for 2 months. After that time period, the fish is sacrificed and found to have a calculated BCF of 0.5. This indicates _____.

Please follow these instructions carefully, as failure to follow them will result in a penalty. (i) Download the Exam template from the class website and use that to write your solutions.  (ii) The solutions to each problem should be in the space specially assigned to them. (iii) When scanning your solutions into a pdf file, each page must be scanned as a separate page and the entire exam as one pdf file. (iv) You have 135 minutes to complete the exam, including the time to scan the exam and upload it as a pdf file to Proctorio   I.  Find all solutions to  the system of equations     x_1+ 3x_2+x_3+x_4=3   2x_1-2x_2+x_3+2x_4=8 3x_1+x_2+2x_3-x_4=-1                     (20 points) II.  Let A denote the coefficient matrix for the system of equations given in I.  i) Find a basis for the Column space of A.  (10 points) ii) Find a basis for the Row space of   (5 points) iii) Find a basis for the Null space of A (10 points) iv) What is the rank of A? What is the nullity of A? (5 points) III. Solve the matrix equation A.x=b, where A= ,  x= and b= by first finding the inverse of the matrix A.(25 points)   IV.  Write the matrix A in III as a product of elementary matrices. (25 points)