From the laboratory video on drug transport you saw a transwell plate that contained “baskets” in which Caco2 or other types of cells could be seeded. After the cells are seeded and form a confluent monolayer, then if you add drug into the “basket”, you are adding drug to the _________ side of the cell layer.
You are comparing three structurally related antihypertensiv…
You are comparing three structurally related antihypertensive agents, which property would you expect for the drug that is most highly protein-bound? Select all that apply.
Biologics are a newer class of drugs that include proteins,…
Biologics are a newer class of drugs that include proteins, cell therapies, vaccines, blood and blood components. Biologics are isolated from natural sources like humans, animals, or microorganisms and may be produced by biotechnology methods. Which of the following statements are true regarding biologics?
Which of the following models commonly used in the developme…
Which of the following models commonly used in the development of antimicrobials is an example of an ex vivo model?
Simple one- or two-compartment models are often used to illu…
Simple one- or two-compartment models are often used to illustrate the various principles of pharmacokinetics. In these simple models, the concept of “compartment” may best be defined as
Select all that apply. Fick’s Law relates the rate of moveme…
Select all that apply. Fick’s Law relates the rate of movement of drug particles across a membrane (dn/dt) to the product of
Which of the following measurements could be used as a pharm…
Which of the following measurements could be used as a pharmacodynamic endpoint? Select all that apply.
All of the following effects listed below can be classified…
All of the following effects listed below can be classified as pharmacodynamic property of a drug during a pre-clinical or clinical study, except
Select all that apply. Factors affecting drug absorption cou…
Select all that apply. Factors affecting drug absorption could include:
Select all that apply. In the equation for the oral bioavail…
Select all that apply. In the equation for the oral bioavailability of a drug dose (D), where Effective Dose = Fa•Fg•Fh•D,