A term infant is admitted to the NICU at 1 hour of life afte…

A term infant is admitted to the NICU at 1 hour of life after requiring brief positive-pressure ventilation at birth. On exam, the infant is lethargic, shows decreased spontaneous activity, has a weak suck, and demonstrates distal flexion with an incomplete Moro reflex. Pupils are constricted but reactive, and there are no observed seizures. Using Sarnat staging of encephalopathy, how should this infant’s condition be classified?

A term infant undergoing therapeutic hypothermia for moderat…

A term infant undergoing therapeutic hypothermia for moderate hypoxic-ischemic encephalopathy (HIE) develops clinical seizures at 8 hours of life. Continuous EEG monitoring confirms electrographic seizure activity. What is the first-line pharmacologic treatment for neonatal seizures in this setting?

A 3 week old infant is being admitted due to persistent hypo…

A 3 week old infant is being admitted due to persistent hypotonia with diminished tendon reflexes. He has had poor feeding with poor weight gain. On exam, he has dolichocephaly, narrow bifrontal diameter, almond-shaped eyes, a small mouth with thin upper lip, downturned corners of mouth, undescended testes, scrotal hypoplasia, a weak cry, and intermittently sounds squeaky. What disorder do you suspect?

A term infant is admitted to the NICU at 1 hour of life afte…

A term infant is admitted to the NICU at 1 hour of life after requiring brief positive-pressure ventilation at birth. On exam, the infant is lethargic, shows decreased spontaneous activity, has a weak suck, and demonstrates distal flexion with an incomplete Moro reflex. Pupils are constricted but reactive, and there are no observed seizures. Using Sarnat staging of encephalopathy, how should this infant’s condition be classified?