An adult patient has a white blood count of 80 × 109/L. The differential has 92% Sudan black B–positive blasts and 8% lymphocytes. Which is most likely?

A patient’s blood smear shows many of the cells seen below along with a regenerative left shift, vacuolization and Dohle bodies.  What is the patient presumably suffering from based on these findings?   

A 27-year-old woman presents with acute bleeding to the emergency department and is found to have a white count of 25.7 x 109L with pancytopenia: hematocrit 27%, platelet count 35 x 109/L, and absolute neutrophil count 0.8 x 109/L. Molecular analysis detects PML-RARA and Cytogenetics revealed t(15,17).  Her peripheral blood smear is below.  What is the most likely condition?  

A 15-year-old boy presents complaining of severe headaches; he has a white count of 76.0 x 109/L, platelet count of 55 x 109/L, and a hematocrit of 33%. When a white cell differential is performed, most of the nucleated cells are blasts. They are CD2, CD4, and CD8 positive. What is the most likely condition? 

Which nonmalignant alteration is associated with poor mucopolysaccharide processing and can be easily confused with toxic granulation? 

Cell dysfunction in the myelodysplastic syndromes may be present in:

An unknown patient sample has many cells with differentiated blasts that contain cerebriform nuclei, prominent nucleoli, and abundant translucent cytoplasm.  Cytochemical stains were performed and the results are as follows:             MPO: Weakly positive     SBB: Weakly positive                 NSE: Positive           SE: Negative  Cytogenetics detected 11q23 on the karyotype for this patient.               What is the most probable diagnosis?

What is the largest challenge when using RNA for molecular testing?

Which statement about hematologic malignancies is correct?

Which of the following is an expected finding in ET?