BCH 4024 OC 3426 SP26 E2 Q19: During platelet activation, phosphatidylserine (PS) must be rapidly moved to the outer leaflet to create a negatively charged surface for coagulation factor binding. A patient with abnormal clot formation shows reduced PS exposure on activated platelets, despite normal ATP levels. Laboratory studies demonstrate loss of Ca²⁺‑dependent bidirectional phospholipid movement. Which of the following membrane proteins is most likely defective?

BCH 4024 OC 3426 SP26 E2 Q13: Which of the following membrane components is most likely to increase in concentration in response to a drop in environmental temperature?

BCH 4024 OC 3426 SP26 E2 Q29: A compound selectively inhibits Complex III of the electron transport chain in cardiac mitochondria. Which of the following outcomes would most likely occur as a result?

The next 2 questions (21-22) are related to the following case: A 22-year-old athlete is experiencing muscle weakness and fatigue. Lab results show elevated intracellular calcium levels and decreased ATP levels in muscle cells. Genetic testing reveals a mutation in a P-type ATPase. BCH 4024 OC 3426 SP26 E2 Q22: The mutation most likely disrupts which of the following steps in the transport cycle?

BCH 4024 OC 3426 SP26 E2 Q26: A novel organism has been found with a unique electron transfer chain. The Eo values for the individual components are as follows: Component A = + 1.004 mv Component B = -0.027 mv Component C = +0.321 mv Component D = -0.064 mv Component E = -0.457 mv What is the likely order of the transfer of electrons in this chain?

BCH 4024 OC 3426 SP26 E2 Q27: A researcher develops a compound that mimics high levels of acetyl-CoA and NADH, selectively activating the PDH kinase. Which of the following outcomes most directly reflects the effects of this compound on PDH activity?

BCH 4024 OC 3426 SP26 E2 Q17: A newly discovered four‑pass membrane protein shows one 22‑residue hydrophobic segment near residue 40 and three similar hydrophobic segments later in the sequence. Lys/Arg clusters are enriched on the loop/intervening sequence between helix 2 and helix 3. Given these observations, which overall orientation is most consistent with membrane topology rules?

BCH 4024 OC 3426 SP26 E2 Q23: Which glycolytic intermediate is directly shared with the pentose phosphate pathway and determines whether glucose flux enters glycolysis or the PPP?

Perform a convolution of matrix A with kernel K with zero padding.     A =  1 2 3 4 0 1 0 2 3 1 2 1 2 0 1 3 K =

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