Consider the experiment that Dr. Tonegawa used to label hipp…
Consider the experiment that Dr. Tonegawa used to label hippocampal neurons that were part of a contextual fear engram with chanelrhodopsin-EYFP. The image below, outlines the protocol. What if some mice were killed at the time indicated by the yellow arrow (testing day 1: while the mice are in Context A, shortly before turning the light on), and some mice were killed at the time indicated by the purple arrow (testing day 1: while the mice are in Context A, shortly after turning the light on), and the brains of the sacrificed mice were stained with an antibody that recognizes zif268? Which statement below is the best hypothesis for what will happen with zif268 expression?