Notice: Function _load_textdomain_just_in_time was called incorrectly. Translation loading for the jwt-auth domain was triggered too early. This is usually an indicator for some code in the plugin or theme running too early. Translations should be loaded at the init action or later. Please see Debugging in WordPress for more information. (This message was added in version 6.7.0.) in /home/forge/wikicram.com/wp-includes/functions.php on line 6121
Notice: Function _load_textdomain_just_in_time was called incorrectly. Translation loading for the wck domain was triggered too early. This is usually an indicator for some code in the plugin or theme running too early. Translations should be loaded at the init action or later. Please see Debugging in WordPress for more information. (This message was added in version 6.7.0.) in /home/forge/wikicram.com/wp-includes/functions.php on line 6121 Endocrine glands secrete their hormones into the: | Wiki CramSkip to main navigationSkip to main contentSkip to footer
Tо chаrаcterize the rоles оf leptin аnd insulin in reproductive hormone modulation and offspring viability in over-conditioned ruminants, addressing key gaps in knowledge relative to undernutrition studies. Objective 1: To evaluate offspring production and viability in over-conditioned female and male ruminants. Hypothesis 1: Over-conditioned ruminants will exhibit reduced offspring viability, with increased miscarriage rates in females and sperm abnormalities in males. Objective 2: To characterize leptin and insulin profiles and their effects on GnRH, LH, and downstream reproductive hormones. Hypothesis 2: Over-conditioning disrupts leptin and insulin regulation, inhibiting GnRH and LH surges, and reducing progesterone, estradiol, and testosterone fluctuations. Objective 3: To assess the effects of feed over-supplementation on leptin and insulin efficiency and subsequent GnRH/LH surges. Hypothesis 3: Feed over-supplementation leads to decreased leptin and insulin efficiency, disrupting kisspeptin signaling and reproductive hormone surges in over-conditioned ruminants. References: Harlow, et al. (2022). The Impact of Undernutrition on KNDy Neurons in Female Lambs. Nestor, et al. (2023). KNDy Neurons as the GnRH Pulse Generator in Ruminants. AIM 11: To investigate the potential of KNDy neurons as key modulators of puberty and GnRH activity in ruminants, addressing their role in neuroendocrine reproductive regulation. Objective 1: To evaluate the impact of neurokinin B absence on puberty onset. Hypothesis 1: Puberty will occur in the absence of neurokinin B, albeit at a delayed rate. Objective 2: To assess the functional consequences of removing specific KNDy neuron components. Hypothesis 2: Neurokinin B function will be significantly impaired in the absence of kisspeptins. Objective 3: To explore the potential of KNDy neurons as natural GnRH agonists or antagonists. Hypothesis 3: Isolated KNDy neurons can function as effective exogenous modulators of GnRH activity.