Following Cycle 3, the patient develops Grade 3 diarrhoea. W…
Following Cycle 3, the patient develops Grade 3 diarrhoea. What action should be taken? (3 marks) The common toxicities criteria are outlined below: Grade 1: Mild toxicity – often asymptomatic or mild symptoms, no intervention needed, treatment can usually continue. Grade 2: Moderate toxicity – symptoms more pronounced, may need intervention (e.g., medication) Grade 3: Severe toxicity – significant symptoms, may require hospitalisation or intensive intervention; likely to lead to treatment delay, dose reduction or even temporary cessation. Grade 4: Life-threatening toxicity – urgent medical intervention required, serious risk to life, definite treatment interruption/adjustment. Grade 5: Death related to the adverse event/toxicity.