Given the consensus sequences for mRNA splicing (see the Dx…
Given the consensus sequences for mRNA splicing (see the Dx resource) and the sequences spanning the 5′ and 3′ splice junctions of the first intron of the human β-globin gene where the first nucleotide of the intron is at position 1 and the last nucleotide of the intron is at position 130, Determine the effect on mRNA splicing for the following mutations. mRNA splicing.png Answer choices: Impaired Not impaired Mutation Effect on mRNA splicing Position 123, A –> C Position 128, U –> C Position 130, G –> A Position 132, C –> A