In this hypothetical scenario, a GWAS revealed 4 variants as…
In this hypothetical scenario, a GWAS revealed 4 variants associated with developing heart murmurs. Three individuals were genotyped at those 4 SNPs to calculate their PRS. Use the data below to calculate their PRS. Winifred Mary Sarah Genetic Variant Effect allele Effect size Genotype Genotype Genotype rs1234 C 0.03 CC CT TT rs2345 T -0.02 TG TG TT rs3456 G 0.09 GA GG AA rs4567 A 0.04 AC AC AA