Is the bolded statement TRUE or FALSE? In class we spent som…
Is the bolded statement TRUE or FALSE? In class we spent some time on the design of the oxygen-binding pocket of both Hb and Mb to illustrate the structural functional relationship within these proteins. The distal His (His E7), as discussed, forms the top portion of the oxygen-binding pocket and the proximal His (His F8), forms the bottom portion and a covalent bond to the heme. We then moved into the allosteric behavior of Hb. Given these topics which of the following statement(s) is (are) true? 56. BPG shifts the equilibrium of Hb’s conformation toward the “T”-state.57. Replacement of the distal His with a Gly side chain would result in a Mb or Hb protein with a decreased affinity for oxygen. 58. Replacement of the distal His with a Trp side chain would result in a Mb or Hb protein with a decreased affinity for carbon monoxide. 59. The distal His can form a hydrogen bond to both oxygen and carbon monoxide.60. If a molecule that binds to Hb causing a shift of Hb’s conformation toward the R-state, the Kd of Hb for oxygen will decrease.