Is the bolded statement TRUE or FALSE? Protein folding is an…
Is the bolded statement TRUE or FALSE? Protein folding is an excellent study in changes within enthalpy, entropy, and free energy and the stabilization of a system in its final state. Given this subject classify the following as true or false. 46. Formation of disulfide bonds can lead to a greater Hbonds formed than Hbonds broken and a negative change in enthalpy for folding. 47. Formation of ionic bonds within the hydrophobic core can lead to a greater Hbonds formed than Hbonds broken and, as a result, a more stable protein (relative to a protein without these interactions). 48. Ionic bonds within the hydrophobic core are stronger than ionic bonds in water. 49. A globular protein typically will not fold in nonpolar environments as it will be entropically unfavorable to do so. 50. Mutation of a cysteine involved in a disulfide bond to serine will increase the protein’s Tm.