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Tо evаluаte the effects оf inhibin immunizаtiоn on fertility outcomes in cattle, focusing on hormonal changes, superovulation protocols, and heat stress mitigation. Objective 1: To determine the effects of inhibin immunization on FSH, estradiol, progesterone, activin 2, and interferon-tau secretion. Hypothesis 1: Inhibin recombinant DNA vaccines will increase FSH secretion, enhancing follicular development but may temporarily reduce progesterone levels due to decreased luteal activity, potentially impacting pregnancy maintenance. Objective 2: To investigate the benefits of inhibin immunization in superovulation and multiple embryo transfer protocols. Hypothesis 2: Increased FSH secretion following inhibin immunization will enhance ovulation rates and follicular development, improving outcomes in superovulation protocols and embryo transfer efficiency. Objective 3: To assess the impact of inhibin immunization on fertility in cattle exposed to heat stress. Hypothesis 3: Combined inhibin vaccination and human chorionic gonadotropin (hCG) administration will enhance follicular development and conception rates under heat stress, offsetting progesterone deficits and supporting pregnancy. References: Chen, F., et al. (2022). Rectifying Cow Infertility Under Heat Stress by Immunization Against Inhibin. Domestic Animal Endocrinology, 80, 106726. Guo, R., et al. (2020). Conception Rate and Hormone Secretion in Cows Immunized Against Inhibin. Animals, 10, 20313.