Nexium V = 16 L CLH = 120 ml/min fup = 0.03 Normal Dose is…
Nexium V = 16 L CLH = 120 ml/min fup = 0.03 Normal Dose is 40 mg daily by mouth (assume all of the drug absorbs and there is no metabolism in the gut) Determine the average steady-state total concentration (mg/L) in a patient with a polymorphism in the CYP2C19 enzyme such that CLint,u is 50% of normal.