Polyketide synthases (PKS) are important biosynthetic assemb…
Polyketide synthases (PKS) are important biosynthetic assembly lines composed of one or more modules that together synthesize an enormous number of structurally diverse secondary metabolites. A minimal PKS module is composed of 4 essential catalytic domains that catalyze one condensation and subsequent release reaction. Answer questions a-d. a. Name the 4 domains and catalytic activity in the order that they have to perform their functions. (2 pts) Domain 1: Domain 2: Domain 3: Domain 4: b. Name the typical starter and extender molecules that are linked together by one PKS catalyzed reaction (1 pt) c. Name the reaction mechanism by which these two molecules are linked together. (1 pt) d. Write down the structural formula of the final reaction product upon release from the PKS after one reaction round. (1 pt)