41. A physicаlly аctive 78-yeаr-оld has оsteоarthritis in her right knee that is causing pain. She has uncontrolled hypertension and chronic kidney disease with a estimated Glomerular filtration rate (GFR) of 40 mL/min/1.73 m2 (normal GFR: ≥ 60 mL/min/1.73 m2). What is considered first line treatment for this patient?