Question 4d: To achieve their study objective authors mentio…
Question 4d: To achieve their study objective authors mention that they used “wo estimands — the treatment policy estimand (… with effects assessed regardless of treatment discontinuation or rescue intervention) and the trial product estimand (effects assessed if the drug or placebo was taken as intended) — … to assess treatment efficacy from different perspectives and accounted for intercurrent events and missing data differently.” What are the two types of analyses they conducted? Briefly (1-2 sentences) describe how these different analytic approaches impact bias and validity of the results.