Questions from Dr. Shyam Mohapatra Select two from followin…
Questions from Dr. Shyam Mohapatra Select two from following three questions (12-14) 12. (14 pts): “Despite the lack of an inherent mechanism of generating diversity as T and B cells, the members of MHC class of proteins generate substantially higher diversity to present the vast universe of peptides.” Explain this statement? What are the mechanisms in place that make this possible? 13. (14 pts): Consider the claim “T cell effector functions are primarily mediated by secreted products”. To what extent is this statement true for CD4 cells and CD8 T cells? Provide one example for each of these cell types that justify the above statement. 14. (a) (7 pts): How would you identify Th1/TH1 and Th2/TH2 cells and how these cells differ in their effector functions? (b) (7 pts): Explain the clinical importance of the TH1 and TH2 cells with one example each of a disease.