Studying the binding site for your drug in an enzyme, you de…
Studying the binding site for your drug in an enzyme, you determine that the binding region has a potential spot to accommodate a hydroxyl on your drug. One isozyme “alpha” possesses a tyrosine in this location. However, the alternative isozyme “beta” (the one you don’t want to target) possesses a phenylalanine. Will this impact your drug’s selectivity?