Suppose that a channel obeys the concerted allosteric model…
Suppose that a channel obeys the concerted allosteric model (see below). The binding of ligand to the R state (the open form) is 20 times as tight as that to the T state (the closed form). In the absence of ligand, the ratio of closed to open channels is 105. If the channel is a tetramer, what is the fraction of open channels when 1, 2, 3, and 4 ligands are bound? The ratio of closed to open channels is 105 when no ligands are bound. The ratio of closed to open channels is when one ligand is bound. The fraction of open channels is . The ratio of closed to open channels is when two ligands are bound. The fraction of open channels is . The ratio of closed to open channels is when three ligands are bound. The fraction of open channels is . The ratio of closed to open channels is when four ligands are bound. The fraction of open channels is .