The clearance of ibuprofen is 4 L/hr and its apparent volume…
The clearance of ibuprofen is 4 L/hr and its apparent volume of distribution (V) is 12 liters. If 800 mg of ibuprofen were administered every 12 hours, what would be the steady-state trough plasma concentration (mg/L)? Assume rapid and complete absorption that approximates i.v. bolus administration.